Research focused on the prodromal period prior to the onset of psychosis is essential for the further development of strategies for early detection, early intervention, and disease pre-emption. Such efforts necessarily require the enrollment of individuals who are at risk of psychosis but have not yet developed a psychotic illness into research and treatment protocols. This work is becoming increasingly internationalized, which warrants special consideration of cultural differences in conceptualization of mental illness and international differences in health care practices and (...) rights regarding research participation. The process of identifying and requesting informed consent from individuals at elevated risk for psychosis requires thoughtful communication about illness risk and often involves the participation of family members. Empirical studies of risk reasoning and decisional capacity in young people and individuals with psychosis suggest that most individuals who are at-risk for psychosis can adequately provide informed consent; however ongoing improvements to tools and procedures are important to ensure that this work proceeds with maximal consideration of relevant ethical issues. This review provides a discussion of these issues in the context of international research efforts. (shrink)

Some philosophers have recently complained that moral theories almost always portray the distresses of ordinary people in moral predicaments as irrational. In the name of having a minimally realistic picture of ethical thought, these philosophers argue that accounts of morality must allow for strong moral dilemmas, choices involving mutually exclusive all-things-considered requirements or jointly exhaustive all-things-considered prohibitions. In this dissertation I clarify and reject several versions of this argument, which I call the argument from experience. ;In chapters one and two (...) I define strong moral dilemmas as essentially involving conflicts of moral reasons, and reject as premature attempts to reduce questions about strong dilemmas to questions about deontic logic. I accept the goal of representing ordinary experience faithfully, and ask whether a theory will necessarily distort that experience if it employs interpretations of 'ought' and 'prohibited' in ways guaranteeing a priori that there are no strong dilemmas. ;The argument from experience claims that people can have a justifiably high degree of confidence that they are in strong moral dilemmas, and in chapter three I question whether people ever have the needed sorts of confidence about the limits of their abilities, the precise location of their wrongdoing, or the futility of continued moral deliberation. ;In chapter four I reject specific arguments based on regret and guilt. The tendency to feel unavoidable agent-regret or guilt allegedly shows that the agent sees the choice as a strong dilemma, and the appropriateness of such distresses allegedly shows that the agent's way of seeing things is rational. I reply that someone can feel agent-regret without endorsing any moral judgment involving 'ought' or 'prohibited', and that guilt is never unavoidably appropriate. ;In chapter five I trace the failure of the argument from experience to the presence in ordinary thought of a notion of blame which is both conceptually guaranteed always to be avoidable and regarded as an infallible indicator of moral requirement and prohibition. I am led to wonder, finally, why this notion of blame should play a privileged role in philosophical pictures of morality. (shrink)

Strong evidence shows that exposure and engagement with the natural world not only improve human wellbeing but can also help promote environmentally friendly behaviors. Human-nature relationships are at the heart of global agendas promoted by international organizations including the World Health Organization’s “One Health” and the United Nations “Ocean Decade.” These agendas demand collaborative multisector interdisciplinary efforts at local, national, and global levels. However, while global agendas highlight global goals for a sustainable world, developing science that directly addresses these agendas (...) from design through to delivery and outputs does not come without its challenges. In this article, we present the outcomes of international meetings between researchers, stakeholders, and policymakers from the United Kingdom and Brazil. We propose a model for interdisciplinary work under such global agendas, particularly the interface between One Health and the UN Ocean Decade and identify three priority research areas closely linked to each other: human-nature connection, conservation-human behavior, and implementation strategies. We also discuss a number of recommendations for moving forward. (shrink)

If we ask ourselves whether ultimate moral conflicts exist, and if we take seriously the goal of capturing ordinary emotional experience in our views about morality, we find the evidence mixed. We might have some reason for concluding that some situations are ultimate moral conflicts, but we also have good reasons of the same kind for concluding that these situations are not ultimate moral conflicts. So this kind of argument does not provide secure enough footing for any sort of powerful (...) criticism of moral theories which deny the existence of ultimate moral conflicts. Those who want to argue for the reality of ultimate moral conflicts can still argue from something other than ordinary emotional experience. Any such alternative strategy, though, will involve a retreat from the idea that ordinary emotional experience provides unambiguous support for the existence of ultimate moral conflicts and a secure point from which to criticize moral theories.I conclude, then, that accepting the reality of ultimate moral conflicts does not allow a truer picture of ordinary emotional experience. I am not sure, though, that this should be good news for those who believe in a moral realm without ultimate moral conflicts. What is most striking about ordinary emotional experience is not its tendency to support one or another picture of the moral realm, with or without ultimate moral conflicts, but its failure to endorse any very determinate picture of a moral realm. This suggests a rather shocking gap in our understanding of the concepts of moral obligation, prohibition, and permission, concepts which, after all, are alleged to play a familiar and vital role in our lives. Perhaps this gap can be filled by arguments beginning somewhere other than ordinary emotional experience. (Although skeptics will point to the failure of deontic logicians to find any decisive reason to choose between accounts that do and do not permit ultimate moral conflicts.) Alternatively, though, the ambiguity of ordinary emotional experience on the question of ultimate moral conflict might provide one kind of support for the suspicion, famously entertained by Elizabeth Anscombe, that the word “ought,” used to refer to a specifically moral realm, is a word “containing no intelligible thought: a word retaining the suggestion of force, and apt to have a strong psychological effect, but which no longer signifies a real concept at all - No content could be found in the notion ‘morally ought’; if it were not that - philosophers try to find an alternative (very fishy) content and to retain the psychological force of the term.” G.E.M. Anscombe, “Modem Moral Philosophy,” Philosophy 33 (1958): 8. (shrink)

This paper critically evaluates the Hong Kong government's recent attempt to introduce cross-curricular themes into the school curriculum. It is agued that the policy failed to have a significant impact because many of its key elements defined the themes as marginal and dispensable. Moreover, the policy embodied a discourse which portrayed teachers as empowered and, consequently, as the primary source of problems of its implementation.

Cytokinins are plant hormones which have long been associated with cell division and plastid differentiation. Recently, they have been found to play a central role also in the growth of plant tumors. Certain phytopathogenic bacteria, notably Agrobacterium tumefaciens and Pseudomonas syringae pv. savastanoi, can incite tumors on dicotyledonous plants and such tumors exhibit growth which is characteristic of the presence of excess auxin and cytokinin. Genes specifying cytokinin biosynthesis have now been isolated from both sets of bacteria. The genes encode (...) prenyl transferase responsible for cytokinin biosynthesis which, upon expression in E. coli,cause the production of the active cytokinin, zeatin. Expression of these genes in association with the plant is responsible for at least part of the tumor phenotype, although the molecular mechanisms of infection by these bacteria are apparently quite dissimilar. There is extensive homology between the cytokinin biosynthetic genes from the two sets of bacteria. (shrink)

This provocative, engaging and important book marks the fiftieth anniversary of the publication of Peter Winch's seminal The Idea of a Social Science . The authors – the first two philosophers, the third a sociologist – have worked together in various permutations before. No-one familiar with their previous publications will be surprised that the dominant voice throughout is Wittgenstein's – that is, Wittgenstein as read ‘resolutely’ by ‘new Wittgensteinians’. They have three principal aims: first, to read Winch's own work in (...) an equally ‘resolute’ way; hence to read ISS as prophylactic and therapeutic in intention, and not as heralding a wonderful or not-so-wonderful new social theory; secondly, to defend Winch against certain persistent charges; and thirdly, to persuade social theorists and philosophers of ‘social science’ that Winch's therapeutic lessons have not yet been assimilated, with the possible exception of a handful of ethnographers and ethnomethodologists.Following a substantial introductory section, Chapters 1 and 2 – respectively, entitled ‘Beyond pluralism, monism, relativism, realism etc.: reassessing Peter Winch’ and ‘Winch and linguistic idealism’ – argue that Winch cannot be seen as an advocate of linguistic idealism or “any of the other ‘isms’ that have been reactively bandied about …. (shrink)

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

A growing interest has been observed among K-12 school educators to incorporate maker pedagogy into science, technology, engineering, and mathematics education to engage students in the design and making process. Both cognitive engagement and emotional engagement of students can be promoted through satisfying the psychological need of relatedness that concerns a sense of connection and belonging. How to support relatedness would influence the effective development of students’ cognitive competencies, namely creativity and critical thinking, and non-cognitive characteristics, namely interest and identity. (...) Therefore, the present study investigated how two relatedness support strategies—real-world problems and mentoring influence the development of student’s STEM-related cognitive competencies and non-cognitive characteristics in STEM marker activities. We implemented a 7-week intervention study with three classes of Grade 9 students in Hong Kong. Three intervention conditions were designed in the experiment, comprising textbook problem, RWP, and RWP with mentoring. Our analysis showed that the differences in creativity among the three groups were non-significant, the RWP and RWPM groups showed stronger critical thinking than the TBP group, and the RWPM group exhibited stronger STEM interest and identity than the other two groups. This study revealed the effectiveness of adopting RWP strategy in developing secondary students’ perceived cognitive competencies and the feasibility of employing a mentoring mechanism for cultivating learners’ perceived non-cognitive characteristics. Hence, we also offered practical suggestions for teachers. (shrink)

Probability is not an unambiguous concept within the sciences or in vernacular language, yet it is fundamental to much of behavior analysis. The present paper examines some problems this ambiguity creates in general,as well as within the experimental analysis of behavior, in particular. As background material, we first introduce the three most common theories of probability in mathematics and science, discussing their advantages and disadvantages, and their relevance to behavior analysis. Next, we discuss the concept of probability as encountered in (...) the writings of B.F. Skinner and in the contemporary behavior analysis more generally, the latter being based on material drawn from the professional literature and from a questionnaire survey. Although the exercise is basically a descriptive one, we do conclude with some suggestions that may promote more effective action on those occasions when behavior analysts speak of "probability.". (shrink)

This article compares two radically opposed views concerning “race” in the first half of the 20th century: the one of Franz Boas , the founder of American cultural anthropology, and the other of Hans F.K. Günther , the most widely read theoretician of race in Nazi Germany. Opposite as their views were, both derived from a similar non-evolutionist German anthropological matrix. The article reconstructs their definitions of racial objects and studies their analyses of racial intermixture. Although both believed that contemporary (...) peoples were racially deeply mixed, Boas moved towards an antiracist conception of race-as-population, whereas Günther moved towards a racist conception of homogenous races in mixed peoples. The comparison shows that the major difference between them concerns their ideals or guiding principles. Their respective ideals seeped into their versions of science and transformed the nature and the significance of their respective ideas. (shrink)

Errol Morris has claimed that Kuhn threw an ashtray at him during a dispute about some matter in the history of science. Morris also claims that Kuhn threw him out of the graduate program at Princeton for disagreeing with him. I argue that Morris’ attack on Kuhn contains some degree of hyperbole. Further, I present evidence that shows that Morris is mistaken about key events during this period. In fact, Kuhn was supportive of Morris in (...) his pursuit of a career in the history of science. (shrink)

In Britiain, it is unlawful,regardless of the motive of the discriminator,to refuse to give a woman a job because of hersex. On the other hand, the U.K. case ofCoker and Osamor v. The Lord Chancellor and theLord Chancellor's Department suggests that itis permissible, by `pre-selecting' anindividual man, to rule out any possible femalecandidates. The singular facts of this caseshould not disguise the troubling conclusionthat while sex (and race) discrimination maysometimes be blatant and deliberate, morefrequently it is subtle and routine. Furthermore, (...) discrimination is much moredifficult to challenge, let alone eradicate,when it is embedded in the system. This notestarts from the premise that, while sexequality requires more than the appointment ofwomen to influential posts, that is, at least,a start and if it is decided in advance thatappointments will be made only from a smallcircle of `acceptable' people there is a realdanger that the idea of the `establishment' asa self-perpetuating (white) male enclave willbe confirmed. (shrink)

This is an edited collection of essays on the changing character of military professionalism and the role of ethics in the 21st century military. The authors are uniformed military, academics, and non-uniformed professionals on the battlefield, and they look at the concepts of Samuel Huntington, Morris Janowitz, and Sir John Hackett, how training and continuing education play a role in defining a profession, and if a universal code of ethics is required for the military as a profession."--Provided by publisher.